Multiple Emulsions: Emphasizing on Industrial Applications

Multiple emulsions generally consist of three phases. They can be O/W/O and W/O/W types of multiple emulsions. Multiple emulsions are prepared by incorporating preformulated macroemulsion (i.e., either O/W or W/O emulsions) into the respective aqueous or oil phase as required with the help of sufficient and appropriate emulsifier. For example, O/W and W/O emulsions are incorporated in oil phase and aqueous phase, respectively. Multiple emulsions are preferred over macroemulsions due to the sustained release mechanism of multiple emulsions that helps in the prolongation of drug release or slow release of drug which further delays/prolongs the drug stay in the body for therapeutic action. Demands for multiple emulsions are increasing as they can also be used as red blood cell substitute, oxygen substitute, bioavailability enhancer, etc. Multiple emulsions are eligible to target bioactivity, and they can also be used in drug overdose treatment. Multiple emulsions have a tendency to enhance the drug absorption in the gastrointestinal tract (GIT) when administered orally. They act as local immunosuppressant as they can reduce the immune system’s activity. Targeted delivery of peptides and proteins can be achieved by using multiple emulsions because they can easily encapsulate peptide or proteins within the innermost layer. Multiple emulsions play a vital role in cosmetics as well as in health-care products; there are various cosmeceutical products available in the market such as moisturizer, sunscreen lotion, cleanser, antiperspirant, shaving cream, etc. for their moisturizing capability, protective nature, cleansing ability, sun protection, etc.

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References

• Allen TM, Murray L, MacKeigan S, Shah M. Chronic liposome administration in mice: effects on reticuloendothelial function and tissue distribution. J Pharmacol Exp Ther. 1984;229:267–75. CASPubMedGoogle Scholar
• Benoy CJ, Schneider R, Elson LA, Jones M. Enhancement of the cancer chemotherapeutic effect of the cell cycle phase specific agents methotrexate and cytosine arabinoside when given as a water-oil-water emulsion. Eu J Cancer (1965). 1974;10:27–33. https://doi.org/10.1016/0014-2964(74)90034-6. ArticleCASGoogle Scholar
• Blanco A, Blanco G. Chapter 3 – Proteins. In: Blanco A, Blanco G, editors. Medical biochemistry. London/San Diego: Academic Press; 2017. p. 21–71. https://doi.org/10.1016/B978-0-12-803550-4.00003-3. ChapterGoogle Scholar
• Borwanker CM, Pfeiffer SB, Zheng S, Beissinger RL, Wasan DT, Sehgal LR, Rosen AL. Formulation and characterization of a multiple emulsion for use as a red blood cell substitute. Biotechnol Prog. 1988;4:210–7. https://doi.org/10.1002/btpr.5420040404. ArticleCASGoogle Scholar
• Chiang C-W, Fuller GC, Frankenfeld JW, Rhodes CT. Potential of liquid membranes for drug overdose treatment: in vitro studies. J Pharm Sci. 1978;67:63–6. https://doi.org/10.1002/jps.2600670117. ArticleCASPubMedGoogle Scholar
• Chow SC. Bioavailability and bioequivalence in drug development. Wiley Interdiscip Rev Comput Stat. 2014;6:304–12. https://doi.org/10.1002/wics.1310. ArticlePubMedPubMed CentralGoogle Scholar
• Coffman RL, Sher A, Seder RA. Vaccine adjuvants: putting innate immunity to work. Immunity. 2010;33:492–503. https://doi.org/10.1016/j.immuni.2010.10.002. ArticleCASPubMedPubMed CentralGoogle Scholar
• Datta S, Christena LR, Rajaram YRS. Enzyme immobilization: an overview on techniques and support materials. 3 Biotech. 2013;3:1–9. https://doi.org/10.1007/s13205-012-0071-7. ArticlePubMedGoogle Scholar
• Di Pasquale A, Preiss S, Tavares Da Silva F, Garçon N. Vaccine adjuvants: from 1920 to 2015 and beyond. Vaccines (Basel). 2015;3:320–43. https://doi.org/10.3390/vaccines3020320. ArticleCASGoogle Scholar
• Ferreira MRA, Santiago RR, de Souza TP, Egito EST, Oliveira EE, Soares LAL. Development and evaluation of emulsions from Carapa guianensis (Andiroba) oil. AAPS PharmSciTech. 2010;11:1383–90. https://doi.org/10.1208/s12249-010-9491-z. ArticleCASPubMedPubMed CentralGoogle Scholar
• Fox CB, Baldwin SL, Duthie MS, Reed SG, Vedvick TS. Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions. Vaccine. 2011;29:9563–72. https://doi.org/10.1016/j.vaccine.2011.08.089. ArticleCASPubMedPubMed CentralGoogle Scholar
• González de Llano D, Polo Sánchez C. PEPTIDES. In: Caballero B, editor. Encyclopedia of food sciences and nutrition. 2nd ed. Oxford: Academic Press; 2003. p. 4468–73. https://doi.org/10.1016/B0-12-227055-X/00906-8. ChapterGoogle Scholar
• Herbert WJ. Multiple emulsions. A new form of mineral-oil antigen adjuvant. Lancet. 1965;286:771. https://doi.org/10.1016/s0140-6736(65)90816-0. ArticleGoogle Scholar
• Illum L, Thomas NW, Davis SS. Effect of a selected suppression of the reticuloendothelial system on the distribution of model carrier particles. J Pharm Sci. 1986;75:16–22. https://doi.org/10.1002/jps.2600750105. ArticleCASPubMedGoogle Scholar
• Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech. 2015;5:123–7. https://doi.org/10.1007/s13205-014-0214-0. ArticlePubMedGoogle Scholar
• Kajita M, Morishita M, Takayama K, Chiba Y, Tokiwa S, Nagai T. Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid. J Pharm Sci. 2000;89:1243–52. https://doi.org/10.1002/1520-6017(200010)89:103.0.CO;2-C ArticleCASGoogle Scholar
• Kesarwani K, Gupta R. Bioavailability enhancers of herbal origin: an overview. Asian Pac J Trop Biomed. 2013;3:253–66. https://doi.org/10.1016/S2221-1691(13)60060-X. ArticleCASPubMedPubMed CentralGoogle Scholar
• Kumar R, Kumar MS, Mahadevan N. Multiple emulsions: a review. Int J Recent Adv Pharm Res. 2012;2:9–19. https://doi.org/10.17010//2012/v5i2/60128. ArticleGoogle Scholar
• Laugel C, Rafidison P, Potard G, Aguadisch L, Baillet A. Modulated release of triterpenic compounds from a O/W/O multiple emulsion formulated with dimethicones: infrared spectrophotometric and differential calorimetric approaches. J Control Release. 2000;63:7–17. https://doi.org/10.1016/s0168-3659(99)00169-8. ArticleCASPubMedGoogle Scholar
• Lazo J, Hacker M. Organ-directed toxicology of antitumor agents. Symposium summary. Fed Proc. 1985;44:2335–8. CASPubMedGoogle Scholar
• Leclercq SY, dos Santos RMM, Macedo LB, Campos PC, Ferreira TC, de Almeida JG, Seniuk JGT, Serakides R, Silva-Cunha A, Fialho SL. Evaluation of water-in-oil-in-water multiple emulsion and microemulsion as potential adjuvants for immunization with rabies antigen. Eur J Pharm Sci. 2011;43:378–85. https://doi.org/10.1016/j.ejps.2011.05.008. ArticleCASPubMedGoogle Scholar
• Lokhande SS. Recent trends in multiple emulsion – a comprehensive review. Asian J Res Pharma Sci. 2019;9:201–8. https://doi.org/10.5958/2231-5659.2019.00032.8. ArticleGoogle Scholar
• Lowinger MB, Barrett SE, Zhang F, Williams RO. Sustained release drug delivery applications of polyurethanes. Pharmaceutics. 2018;10:55. https://doi.org/10.3390/pharmaceutics10020055. ArticleCASPubMed CentralGoogle Scholar
• May SW, Li NN. Encapsulation of enzymes in liquid membrane emulsions. In: Pye EK, Wingard LB, editors. Enzyme engineering, vol. 2. Boston: Springer US; 1974. p. 77–82. https://doi.org/10.1007/978-1-4615-8897-9_11. ChapterGoogle Scholar
• Mishra B, Sahoo BL, Mishra M, Shukla D, Kumar V. Design of a controlled release liquid formulation of lamotrigine. Daru. 2011;19:126–37. CASPubMedPubMed CentralGoogle Scholar
• Nafisi S, Maibach HI. Chapter 22 – nanotechnology in cosmetics. In: Sakamoto K, Lochhead RY, Maibach HI, Yamashita Y, editors. Cosmetic science and technology. Amsterdam: Elsevier; 2017. p. 337–69. https://doi.org/10.1016/B978-0-12-802005-0.00022-7. ChapterGoogle Scholar
• Oh I, Kang YG, Lee YB, Shin SC, Kim CK. Prolonged release of tegafur from S/O/W multiple emulsion. Drug Dev Ind Pharm. 1998;24:889–94. https://doi.org/10.3109/03639049809097268. ArticleCASPubMedGoogle Scholar
• Omotosho JA, Whateley TL, Florence AT. Methotrexate transport from the internal phase of multiple w/o/w emulsions. J Microencapsul. 1989;6:183–92. https://doi.org/10.3109/02652048909098019. ArticleCASPubMedGoogle Scholar
• Omotosho JA, Florence AT, Whateley TL. Absorption and lymphatic uptake of 5-fluorouracil in the rat following oral administration of w/o/w multiple emulsions. Int J Pharm. 1990;61:51–6. https://doi.org/10.1016/0378-5173(90)90043-4. ArticleCASGoogle Scholar
• Patel KR, Li MP, Baldeschwieler JD. Suppression of liver uptake of liposomes by dextran sulfate 500. Proc Natl Acad Sci U S A. 1983;80:6518–22. https://doi.org/10.1073/pnas.80.21.6518. ArticleCASPubMedPubMed CentralGoogle Scholar
• Pretorius E. The adaptability of red blood cells. Cardiovasc Diabetol. 2013;12:63. https://doi.org/10.1186/1475-2840-12-63. ArticleCASPubMedPubMed CentralGoogle Scholar
• Santos DI, Saraiva JMA, Vicente AA, Moldão-Martins M. 2-Methods for determining bioavailability and bioaccessibility of bioactive compounds and nutrients. In: Barba FJ, Saraiva JMA, Cravotto G, Lorenzo JM, editors. Innovative thermal and non-thermal processing, Bioaccessibility and Bioavailability of Nutrients and Bioactive Compounds. Sawston: Woodhead Publishing; 2019. p. 23–54. https://doi.org/10.1016/B978-0-12-814174-8.00002-0. ChapterGoogle Scholar
• Siriwardhana N, Kalupahana NS, Cekanova M, LeMieux M, Greer B, Moustaid-Moussa N. Modulation of adipose tissue inflammation by bioactive food compounds. J Nutr Biochem. 2013;24:613–23. https://doi.org/10.1016/j.jnutbio.2012.12.013. ArticleCASPubMedGoogle Scholar
• Streilein JW, Taylor AW. Local immunosuppression: the eye. In: Thomson AW, editor. Therapeutic immunosuppression, immunology and medicine series. Dordrecht: Springer; 2001. p. 275–321. https://doi.org/10.1007/978-94-010-0765-8_11. ChapterGoogle Scholar
• Takahashi T, Mizuno M, Fujita Y, Ueda S, Nishioka B, Majima S. Increased concentration of anticancer agents in regional lymph nodes by fat emulsions, with special reference to chemotherapy of metastasis. GANN Japan J Cancer Res. 1973;64:345–350_1. https://doi.org/10.20772/cancersci1959.64.4_345. ArticleCASGoogle Scholar
• Talegaonkar S, Vyas SP. Inverse targeting of diclofenac sodium to reticuloendothelial system-rich organs by sphere-in-oil-in-water (s/o/w) multiple emulsion containing poloxamer 403. J Drug Target. 2005;13:173–8. https://doi.org/10.1080/10611860500065104. ArticleCASPubMedGoogle Scholar
• Tamer T, Omer A, Hassan M. Methods of enzyme immobilization. Int J Curr Pharma Rev Res. 2016;7:385–92. Google Scholar
• Toorisaka E, Ono H, Arimori K, Kamiya N, Goto M. Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion. Int J Pharm. 2003;252:271–4. https://doi.org/10.1016/s0378-5173(02)00674-9. ArticleCASPubMedGoogle Scholar
• Vaziri A, Warburton B. Slow release of chloroquine phosphate from multiple taste-masked W/O/W multiple emulsions. J Microencapsul. 1994;11:641–8. https://doi.org/10.3109/02652049409051114. ArticleCASPubMedGoogle Scholar
• Verma R, Jaiswal TN. Protection, humoral and cell-mediated immune responses in calves immunized with multiple emulsion haemorrhagic septicaemia vaccine. Vaccine. 1997;15:1254–60. https://doi.org/10.1016/s0264-410x(97)00025-x. ArticleCASPubMedGoogle Scholar
• Vladisavljević GT, Williams RA. Recent developments in manufacturing emulsions and particulate products using membranes. Adv Colloid Interface Sci. 2005;113:1–20. https://doi.org/10.1016/j.cis.2004.10.002. ArticleCASPubMedGoogle Scholar
• Yun YH, Lee BK, Park K. Controlled drug delivery: historical perspective for the next generation. J Control Release. 2015;219:2–7. https://doi.org/10.1016/j.jconrel.2015.10.005. ArticleCASPubMedPubMed CentralGoogle Scholar
• Zheng S, Zheng Y, Beissinger RL, Wasan DT, McCormick DL. Hemoglobin multiple emulsion as an oxygen delivery system. Biochim Biophys Acta. 1993;1158:65–74. https://doi.org/10.1016/0304-4165(93)90098-s. ArticleCASPubMedGoogle Scholar

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Authors and Affiliations

1. Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India Pratishtha & Swati Gupta
2. SGT College of Pharmacy, SGT University, Gurugram, India Manish Kumar Gupta

1. Pratishtha